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CARDURA® (doxazosin mesylate tablets) Drug Interactions

7 DRUG INTERACTIONS

7.1. CYP 3A Inhibitors

In vitro studies suggest that doxazosin is a substrate of CYP 3A4. Strong CYP3A inhibitors may increase exposure to doxazosin. Monitor blood pressure and for symptoms of hypotension when CARDURA is used concomitantly with strong CYP3A inhibitors [see Clinical Pharmacology (12.3)].

7.2 Phosphodiesterase-5 (PDE-5) inhibitors

Concomitant administration of CARDURA with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension. Monitor blood pressure and for symptoms of hypotension [see Warnings and Precautions (5.1)].

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